Endocrine Abstracts

Objective: To evaluate the results of the early postoperative low-dose (1 μg) ACTH (adrenocorticotropin) stimulation test in patients with Cushing’s disease (CD) in order to predict long-term outcome of transsphenoidal surgery.Methods: We reviewed the serum cortisol response to 1 μg synthetic ACTH (1–24) in the second week after pituitary surgery in 40 patients with Cushing’s disease. Median follow-up was 48.5 months (range 6&#15...

Introduction: The steroidogenesis inhibitors ketoconazole and metyrapone are frequently used for treatment of Cushing’s syndrome, but can cause side effects. LCI699 is a known 11β-hydroxylase inhibitor, but effects on other steroidogenic enzymes are unknown. We aimed to compare effects of LCI699, ketoconazole, and metyrapone in vitro.Methods: HAC-15 cells, with or without 10 nM ACTH, and three primary human adrenocortical adenoma cultu...

Polycystic ovary syndrome (PCOS) is characterized by anovulation, hyperandrogenemia, and polycystic ovaries. Although the etiology of PCOS is poorly understood, the common denominator is a disturbance in the selection of the dominant follicle. TGFβ family members, such as anti-Müllerian hormone (AMH) and bone morphogenetic proteins (BMPs), suppress FSH sensitivity. Therefore their signaling pathway may contribute to the aberrant follicle development in PCOS women. We...

Polycystic ovary syndrome (PCOS) is characterized by anovulation, elevated levels of circulating androgens and polycystic ovaries. Although the etiology of PCOS is poorly understood, the common denominator is a disturbance in the selection of the dominant follicle. In PCOS women serum Anti-Müllerian Hormone (AMH) levels are elevated. Since AMH reduces FSH sensitivity of growing follicles, the elevated AMH levels in PCOS patients may contribute to the disturbed follicle se...